|
T20545 |
Benzarone
|
Benzarona,Vasoc,Venagil,Benzaronum |
OAT
|
|
Benzarone (Benzarona) is a potent inhibitor of human uric acid transporter 1 (URAT1, IC50 = 2.8 μM in oocyte). Benzarone lowers the level of uric acid serum. |
|
T2397 |
Topiroxostat
|
FYX-051 |
P450
,
ROS
,
Xanthine Oxidase
|
|
Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout. |
|
T15251 |
Etebenecid
|
Urelim |
Others
|
|
Etebenecid (Urelim) is uricosuric agents, which lower uric acid levels in the body by increasing the elimination of uric acid by the kidneys. It also inhibits penicillin tubular secretion. |
|
T21302 |
UNC569
|
UNC 569 |
TAM Receptor
|
|
UNC569 (UNC 569) is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. UNC569 could normalize the amoun... |
|
T79854 |
Lingdolinurad
|
|
OAT
|
|
Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout. |
|
T5987 |
Potassium oxonate
|
Oxonic Acid (potassium salt),Potassium otastat,Potassium azaorotate |
Others
|
|
Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. |
|
T60625 |
Tigulixostat
|
LC350189 |
Xanthine Oxidase
|
|
Tigulixostat (LC350189) is a novel xanthine oxidase inhibitor (XOI) that reduces uric acid production and may be used in studies of gout-related diseases. |
|
T21469 |
Cyclopenthiazide
|
Cyclomethiazide,Su-8341,SU 8341 |
Others
|
|
Cyclopenthiazide (Cyclomethiazide) is a thiazide diuretic used to treat hypertension and heart failure. It decreases the excretion of calcium ions and uric acid and increases the excretion of sodium and potassium ions. |
|
T6875 |
Lesinurad
|
RDEA594 |
OAT
|
|
Lesinurad (RDEA594) is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with seru... |
|
T61048 |
Puliginurad
|
YL-90148 |
OAT
|
|
Puliginurad (YL-90148) is a potent and selective inhibitor of urate transporter protein (URAT) with inhibitory effects on uric acid reabsorption.Puliginurad can be used for the prevention and treatment of hyperuricemia a... |
|
T26619 |
Amitivir
|
LY217896,LY 217896,LY-217896 |
Others
,
Influenza Virus
|
|
Amitivir (LY 217896) is an inosine monophosphate dehydrogenase inhibitor. Amitivir inhibits the replication of dividing MDCK cells. Amitivir was associated with asymptomatic rises in serum uric acid levels and was ineffe... |
|
T77517 |
URAT1 inhibitor 7
|
|
OAT
|
|
URAT1 inhibitor 7 is a novel and potent inhibitor of the human uric acid transporter protein URAT1 (IC50:12 nM).URAT1 inhibitor 7 inhibits CYP2C9 with an IC50 of 4.2 μM.URAT1 inhibitor 7 can be used to study hyperuricemi... |
|
T0782 |
Benzthiazide
|
Aquatag,Lemazide,Dihydrex |
Carbonic Anhydrase
|
|
Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ... |
|
T20548 |
Parabanic acid
|
NSC9789,NSC-9789,NSC 9789 |
|
|
Parabanic acid is the oxidation product of uric acid by singlet oxygen. |
|
T26490 |
AA 193
|
AA-193,AA193 |
|
|
AA 193 selectively inhibits the presecretory reabsorption of uric acid. |
|
T27697 |
JTT-552
|
|
|
|
JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia. |
|
T13259 |
URAT1 inhibitor 1
|
|
OAT
|
|
URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout. |
|
T68437 |
Febuxostat 67M-1
|
|
|
|
Febuxostat 67M-1 is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation. |
|
T71808 |
Tisopurine
|
|
|
|
Tisopurine is a drug used in the treatment of gout in some countries. It reduces uric acid production through inhibiting an early stage in its production. |
|
T26710 |
Azapropazone
|
DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85 |
|
|
Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable ... |
|
T69281 |
Febuxostat 67M-4
|
|
|
|
Febuxostat 67M-4 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation. |
|
T69282 |
Febuxostat 67M-2
|
|
|
|
Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation. |
|
T76104 |
Xanthine oxidase
|
|
|
|
Xanthine oxidase, a xanthine oxidoreductase enzyme, catalyzes the oxidation of hypoxanthine to xanthine and further oxidizes xanthine to uric acid, generating reactive oxygen species (ROS) [1]. |
|
T71326 |
1,3,7-Trimethyluric Acid-d9
|
|
|
|
1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffei... |
|
T73617 |
Urate oxidase
|
|
|
|
Urate oxidase (Uox), also known as uricase, is a peroxisomal enzyme widely utilized in biochemical research. It catalyzes the conversion of uric acid to allantoin in the majority of mammals [1]. |
|
T79177 |
URAT1&XO inhibitor 2
|
|
Xanthine Oxidase
|
|
Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in H... |
|
T60626 |
Xanthine oxidase-IN-7
|
|
|
|
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active xanthine oxidase(XO) inhibitor (IC50 = 0.36 μM). Xanthine oxidase-IN-7 effectively reduces serum uric acid levels which has the potential in the hyperuricem... |
|
T60935 |
H-Tyr-Phe-OH
|
|
|
|
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) can be used as the biomarker to distinguish benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH is an orally active Angiotensin-converting enzyme inhibitor with t... |
|
T36660 |
Olsalazine-13C6
|
Olsalazine-13C6 |
|
|
Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that... |
